Collaborative framework in computer aided innovation 2.0 : Application to process system engineering

In economy nowadays, the act of innovation is in general social; it requires the management of knowledge, and the techniques and methodologies to drive it. Innovation is not the product of one isolated intelligence, instead, it is the result of a multi-disciplinary workgroup lead by a process or a methodology. The conceptual design, which is found in the first stages of the innovation process, represents one of the most important challenges in industry nowadays. One of the main challenges faced by chemical industries related to the conceptual design phase is to provide the means in the form of methods and computational tools, for solving problems systematically, at the same time that benefiting from the collective efforts of individual intelligences involved. Hence, the main objective of this work is to provide a solution to improve the creative capacity of a team involved in the innovation process, in particular the preliminary (critical) phase of conceptual design. Consequently, it is important to understand the techniques, methods and tools that best support the generation of novel ideas and creative solutions. In addition, it is necessary to study the contribution of information and communication technologies as the mean to support collaboration. Web technologies are considered as complementary tools to implement methods and techniques in collaborative design, and particularly in the conceptual design stage. These technologies allow setting up distributed collaborative environments to bring together the resources and the experts who can relate the existing pieces of knowledge to new contexts. It is the synergy created in this kind of environment, which allow producing valuable concepts and ideas in the form of Collective Intelligence. Nevertheless in most existing solutions for collective intelligence or crowdsourcing environments, they do not report the use of a particular methodology to improve the participants' creativity. The solution in this work describes a social network service that enables users to cooperatively solve problems oriented (but not limited) to the phase of conceptual design. In this work we propose that the use of Collective Intelligence in combination with the model TRIZ-CBR could lead the creative efforts in a team to develop innovative solutions. With this work we are looking for connecting experts from one particular field, TRIZ practitioners and stakeholders with the objective to solve problems in collaboration unlashing the collective intelligence to improve creativity. This work uses the basis of the concept named "Open CAI 2.0" to propose a solution in the form of a theoretical framework. The contributions seek to move the development of the field in Computer Aided Innovation a step forward

Collective Intelligence to solve creative problems in conceptual design phase

In industry, there is an interest in the collective resolution of creative problems found on the phase of conceptual design. In this work we introduce an information-based software framework for collaboration in the problem resolution process. This framework proposes the implementation of techniques from the collective intelligence research field in combination with the systematic methods provided by TRIZ theory. Both approaches are centered in the human aspect of the innovation process, and are complementary. While collective intelligence focuses on the intelligence or behavior that emerges in collaborative work, the TRIZ theory is centered in the individual's capacity to solve problems. The framework's objective is to improve the individual creativity provided by TRIZ method and tools, with the value created by the collective contributions. This work aims to expand the horizon in the field of computer aided innovation (CAI), to the next evolutionary step called Open CAI 2.0

Management of «Systematic Innovation»: A kind of quest for the Holy Grail!

In this paper, authors propose a contribution for improving the open innovation processes. It shows the necessity to get an efficient methodology for open innovation in order to build a computer aided tool for inventive design in Process Systems Engineering (PSE). The proposed methodology will be evocated to be fully used in the context of the “revolutionary” concepts around the so-called factory for the future, also called integrated digital factory, innovative factory… As a result the main contribution of this paper is to propose a software prototype for an Open Computer Aided Innovation 2.0. By definition this open innovation relies on collaboration. This collaboration should enable a community, with a very broad spectrum of skills, to share data, information, knowledge and ideas. As a consequence, a first sub objective is to create a methodological framework that takes advantages of collaboration and collective intelligence (with its capacity to join intelligence and knowledge). Furthermore, the raise of the digital company and more particularly the breakthroughs in information technologies is a powerful enabler to extend and improve the potential of collective intelligence. The second sub objective is to propose a problem resolution process to impel creativity of expert but also to develop, validate and select innovative solutions. After dealing with the importance of Process Innovation and Problem solving investigation in PSE, the proposed approach originally based on an extension of the TRIZ theory (Russian acronym for Theory of Inventive Problem Solving), has been improved by using approach such as case-based reasoning, in order to tackle and revisit problems encountered in the PSE. A case study on biomass is used to illustrate the capabilities of the methodology and the tool

Using the Collective Intelligence for inventive problem solving: A contribution for Open Computer Aided Innovation

In the industrial context, an interest exists in the collective resolution of creative problems during the conceptual design phase. In this work we introduce an information-based software framework useful to collaborate for inventive problems solving. This framework proposes the implementation of techniques from the Collective Intelligence (CI) research field in combination with the systematic methods provided by the TRIZ theory. Both approaches are centered in the human aspect of the innovation process, and are complementary. While CI focuses on the intelligent behavior that emerges in collaborative work, the TRIZ theory is centered in the individual capacity to solve problems systematically. The framework's objective is to improve the individual creativity provided by the TRIZ method and tools, with the value created by the collective contributions. This work aims to contribute formulating the basis to extend the research field of Computer Aided Innovation, to the next evolutionary step called “Open CAI 2.0”

Open computer aided innovation to promote innovation in process engineering

Recent advances in theoretical approaches to innovation and in information and communication technologies provide a more structured knowledge-driven environment for inventors, designers and engineers. Consequently, a new category of tools known as computer aided innovation (CAI) has emerged, with goals of assisting designers in their creative performance and of effectively implementing a complete innovation process throughout the entire product or process life cycle. Based on the concept of Open CAI 2.0 introduced by Hüsig and Kohn (2011), this paper goes further by proposing a prototype software tool for the next evolutionary step of CAI arising from two major recent developments: new advances in technological possibilities in the software field commonly referred to as “Web 2.0” and a strategic paradigm shift from closed to open innovation in many companies. This contribution is one of the first attempts to create a concrete methodological framework based on collective intelligence (through Web 2.0 practices), a collaboration support (with the benefits of on-line social networks) and a problem resolution process. In the proposed Open CAI 2.0, the inventive problem solving method is inspired by the coupling between the innovation theory TRIZ and case based reasoning in order to support the generation of inventive technological solutions because problem solving often requires a reformulation of the initial problem to construct an abstract model of the problem. This paper highlights the importance of knowledge acquisition, capitalization and reuse as well as the problem formulation and resolution in collaboration. A case study on biomass gasification is used to illustrate the method and tool capabilities in the chemical process industry

The relevance of the UPS in the fatty liver graft preservation: a new approach for IGL-1 and HTK solutions

The 26S proteasome is the central proteolytic machinery of the ubiquitin proteasome system (UPS), which is involved in the degradation of ubiquitinated protein substrates. Recently, UPS inhibition has been shown to be a key factor in fatty liver graft preservation during organ cold storage using University of Wisconsin solution (UW) and Institute Georges Lopez (IGL-1) solutions. However, the merits of IGL-1 and histidine-tryptophan-ketoglutarate (HTK) solutions for fatty liver preservation have not been compared. Fatty liver grafts from obese Zücker rats were preserved for 24 h at 4 °C. Aspartate aminotransferase and alanine aminotransferase (AST/ALT), glutamate dehydrogenase (GLDH), ATP, adenosine monophosphate protein kinase (AMPK), e-NOS, proteasome activity and liver polyubiquitinated proteins were determined. IGL-1 solution prevented ATP breakdown during cold-storage preservation of steatotic livers to a greater extent than HTK solution. There were concomitant increases in AMPK activation, e-NOS (endothelial NOS (NO synthase)) expression and UPS inhibition. UPS activity is closely related to the composition of the solution used to preserve the organ. IGL-1 solution provided significantly better protection against ischemia-reperfusion for cold-stored fatty liver grafts than HTK solution. The effect is exerted through the activation of the protective AMPK signaling pathway, an increase in e-NOS expression and a dysregulation of the UPS

Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury

Institut George Lopez-1 (IGL-1) and Histidine-tryptophan-ketoglutarate (HTK) solutions are proposed as alternatives to UW (gold standard) in liver preservation. Their composition differs in terms of the presence/absence of oncotic agents such as HES or PEG, and is decisive for graft conservation before transplantation. This is especially so when fatty (steatotic) livers are used since these grafts are more vulnerable to ischemia insult during conservation. Their composition determines the extent of the subsequent reperfusion injury after transplantation. Aldehyde dehydrogenase-2 (ALDH2), a mitochondrial enzyme, has been reported to play a protective role in warm ischemia-reperfusion injury (IRI), but its potential in fatty liver cold ischemic injury has not yet been investigated. We evaluated the relevance of ALDH2 activity in cold ischemia injury when fatty liver grafts from Zucker Obese rats were preserved in UW, HTK, and IGL-1 solutions, in order to study the mechanisms involved. ALDH2 upregulation was highest in livers preserved in IGL-1. It was accompanied by a decrease in transaminases, apoptosis (Caspase 3 and TUNEL assay), and lipoperoxidation, which was concomitant with the effective clearance of toxic aldehydes such as 4-hydroxy-nonenal. Variations in ATP levels were also determined. The results were consistent with levels of NF-E2 p45-related factor 2 (Nrf2), an antioxidant factor. Here we report for the first time the relevance of mitochondrial ALDH2 in fatty liver cold preservation and suggest that ALDH2 could be considered a potential therapeutic target or regulator in clinical transplantation

Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK

Institute Goeorges Lopez 1 (IGL-1) and Histidine-Tryptophan-Ketoglutarate (HTK) preservation solutions are regularly used in clinical for liver transplantation besides University of Wisconsin (UW) solution and Celsior. Several clinical trials and experimental works have been carried out comparing all the solutions, however the comparative IGL-1 and HTK appraisals are poor; especially when they deal with the underlying protection mechanisms of the fatty liver graft during cold storage. Fatty livers from male obese Zücker rats were conserved for 24 h at 4 °C in IGL-1 or HTK preservation solutions. After organ recovery and rinsing of fatty liver grafts with Ringer Lactate solution, we measured the changes in mechanistic target of rapamycin (mTOR) signaling activation, liver autophagy markers (Beclin-1, Beclin-2, LC3B and ATG7) and apoptotic markers (caspase 3, caspase 9 and TUNEL). These determinations were correlated with the prevention of liver injury (aspartate and alanine aminostransferase (AST/ALT), histology) and mitochondrial damage (glutamate dehydrogenase (GLDH) and confocal microscopy findings). Liver grafts preserved in IGL-1 solution showed a marked reduction on p-TOR/mTOR ratio when compared to HTK. This was concomitant with significant increased cyto-protective autophagy and prevention of liver apoptosis, including inflammatory cytokines such as HMGB1. Together, our results revealed that IGL-1 preservation solution better protected fatty liver grafts against cold ischemia damage than HTK solution. IGL-1 protection was associated with a reduced liver damage, higher induced autophagy and decreased apoptosis. All these effects would contribute to limit the subsequent extension of reperfusion injury after graft revascularization in liver transplantation procedures

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries(1,2). However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world(3) and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health(4,5). However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular riskchanged from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.Peer reviewe